Assay

Pyruvate dehydrogenase antibodies

Key Words

Pyruvate dehydrogenase antibodies, PYDH, M2, LAB

Specimen Collection

Serum (brown)

Turnaround time

14 days

Test indications

The subtypes of antimitochondrial antibodies (see above in liver auto-antibodies) associated with primary biliary cirrhosis are M2, M4, M8 and in early disease M9. Antibodies to pyruvate dehydrogenase subunits are M2 antibodies and are present in most patients with PBC. Testing for pyruvate dehydrogenase antibodies is requested by the lab when anti-mitochondrial antibodies are detected by the liver antibody screen.

Methodology

Euroline Immunoblot

Interferences

None

Reference Range

Negative

Analytical error

N/A

Reference change value

N/A

Minimum retesting interval

Repeat testing of pyruvate dehydrogenase antibodies is not usually indicated. Please contact the Immunology laboratory if a repeat is required.