Background

An M-protein (otherwise known as a paraprotein) is a monoclonal

immunoglobulin secreted by an abnormally expanded clone of plasma cells.

How common is MGUS and what happens with time? 

Frequency of MGUS increases with age.

Age MGUS prevalence

>50 years 3.2%

>70 years 5.3%

>85 years 7.5%

Approximately 1% per year will develop a myeloma or low grade lymphoma. Small paraproteins may also occur transiently during infection or inflammation.

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