Assay

HMGCoA reductase antibodies (3-hydroxy-3-methylglutaryl-CoA reductase autoantibodies)

Key Words

HMGCoA reductase abs, HMGC

Specimen Collection

Serum (Brown)

Turnaround time

14 working days

This test is referred to another centre:

Churchill Hospital

Old Road

Headington

Oxford

OX3 7LE

0300 304 7777

Test indications

HMGCR autoantibodies have been shown to be a myositis specific autoantibodies that are strongly associated with immune mediated necrotising myopathy. HMGCR autoantibodies positive patients present with progressive, irritable myopathy of the proximal muscles, with oedema on MRI and a creatinine kinase typically 10x the upper limit of normal.

Methodology

Chemilluminescence

Interferences

Contact referral lab

Reference Range

Negative = <14.9 CU/ml

Equivocal = 15-24.9 CU/ml

Positive = >25 CU/ml

Analytical error

Contact referral lab

Reference change value

Contact referral lab