Assay

Islet tyrosine phosphatase 2 (IA2) antibodies

Key Words

IA2 antibodies, IA2A

Specimen Collection

Serum (Brown)

Turnaround time

14 days

This test is referred to another centre:

Department of Clinical Chemistry and Immunology

Level 4

Addenbrooke’s Hospital NHS Trust

Hills Road

Cambridge

CB2 2QQ

01223 217215

Test indications

Autoantibodies to IA2, a member of the protein tyrosine phosphatase family, are found in 50-75% of type 1 diabetic patients at and prior to disease onset. They are generally more prevalent in younger onset patients and are associated with rapid progression to disease onset.

The combination of two or more autoantibodies gives a higher positive predictive value for Type 1 Diabetes Mellitus than any single autoantibody.

Methodology

ELISA

Interferences

Contact referral lab

Reference Range

0-10 IU/mL

Analytical error

Contact referral lab

Reference change value

Contact referral lab