Annals of Clinical Biochemistry, Ahead of Print.
BackgroundAlbuminuria is an early marker of kidney damage and an essential component of chronic kidney disease (CKD) risk stratification. Quantitative measurement of the urine albumin-to-creatinine ratio (ACR) in a spot, preferably morning, urine sample ...

Annals of Clinical Biochemistry, Ahead of Print.
ObjectivesThe objective of this study was to develop deep learning models for the automated classification of serum protein electrophoresis (SPE) and immunofixation electrophoresis (IFE) images into oncologic, non-oncologic, and healthy categories, and to ...

Annals of Clinical Biochemistry, Ahead of Print.
BackgroundArtificial intelligence (AI) is increasingly recognized as transformative in laboratory medicine, yet adoption lags behind radiology and cardiology. Limited data exist on AI-related attitudes and perceived barriers in Turkish clinical ...

Annals of Clinical Biochemistry, Ahead of Print.
BackgroundA growing body of evidence suggests that male infertility is a precursor to future health problems. This study aimed to develop a unique circulating biomarker that could contribute to the diagnosis of male infertility.Materials and methodsThe ...

Annals of Clinical Biochemistry, Ahead of Print.
BackgroundSample stability represents a major challenge in the preanalytical phase of urinalysis. This study aimed to evaluate and compare the stability of urine samples stored at room temperature for up to 72 h in two commercially available chlorhexidine-...

Annals of Clinical Biochemistry, Ahead of Print.
BackgroundCapillary blood collection offers a less burdensome alternative to venous sampling and may improve access to laboratory testing in resource-limited settings. However, manual procedures can yield pre-analytical variation, resulting in the need ...

Annals of Clinical Biochemistry, Ahead of Print.
BackgroundTotal protein (TP) is a key indicator to differentiate between pleural effusion (PE) and ascites as exudate or transudate. Rapid quantification of TP can provide more accurate clinical treatment.ObjectiveThis study developed a smartphone-based ...

Annals of Clinical Biochemistry, Ahead of Print.
BackgroundChronic kidney disease (CKD) prevalence and prognosis are currently based exclusively on glomerular functions, but the kidney tubule possesses numerous additional functions with pathophysiological and prognostic value. Tubular secretion is also ...

Annals of Clinical Biochemistry, Ahead of Print.
BackgroundThe significance level specified for a statistical analysis indicates the expected false positive rate. Failure to confine false positives to their expected rates can lead to misleading conclusions and especially in studies investigating ...

Annals of Clinical Biochemistry, Ahead of Print.
BackgroundVitamin B12 deficiency can cause anaemia, fatigue, and neurological sequelae. Total B12 assays may not be reflective of tissue B12. Methylmalonic acid (MMA) can assess tissue B12 more accurately. NICE published clinical guidelines on Vitamin B12 ...

Annals of Clinical Biochemistry, Ahead of Print.
IntroductionWhile conclusions regarding the effects of serum separator tubes on some laboratory tests have been reached in previous studies, the effects of these tubes on the B12 test have not been adequately investigated. This study aimed to determine ...