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Table of Contents for Annals of Clinical Biochemistry. List of articles from both the latest and ahead of print issues.
Updated: 2 min 56 sec ago
Strengthening pre-analytic management of biotin interference in clinical immunoassays
Annals of Clinical Biochemistry, Ahead of Print.
Clinical significance of inter-assay discrepancies in serum CA19-9 values: A comparison between CLIA and ECLIA
Annals of Clinical Biochemistry, Ahead of Print.
BackgroundSerum carbohydrate antigen 19-9 (CA19-9) is widely used in the management of pancreatic diseases, but results often vary across immunoassay platforms. This study sought to describe how the values obtained by chemiluminescent immunoassay (CLIA) ...
BackgroundSerum carbohydrate antigen 19-9 (CA19-9) is widely used in the management of pancreatic diseases, but results often vary across immunoassay platforms. This study sought to describe how the values obtained by chemiluminescent immunoassay (CLIA) ...
Insulin/C-peptide interpretation in infants with hypoglycaemia of unknown origin
Annals of Clinical Biochemistry, Ahead of Print.
BackgroundHypoglycaemia is not a disease per se but a manifestation of underlying perturbations of glucose homoeostasis. Among the biochemical tests commonly requested in newborns with confirmed, persistent/recurrent hypoglycaemia of unknown origin is the ...
BackgroundHypoglycaemia is not a disease per se but a manifestation of underlying perturbations of glucose homoeostasis. Among the biochemical tests commonly requested in newborns with confirmed, persistent/recurrent hypoglycaemia of unknown origin is the ...
Reduction in sample recollection number following the implementation of automated pre-analytical interference detection in coagulation testing
Annals of Clinical Biochemistry, Ahead of Print.
BackgroundPre-analytical interferents such as hemolysis, lipemia, and icterus are major sources of error in coagulation testing and frequently lead to sample recollection. Visual inspection, although widely used, is subjective and may fail to identify ...
BackgroundPre-analytical interferents such as hemolysis, lipemia, and icterus are major sources of error in coagulation testing and frequently lead to sample recollection. Visual inspection, although widely used, is subjective and may fail to identify ...
Machine learning for the identification of mild to moderate EDTA contamination of serum samples
Annals of Clinical Biochemistry, Ahead of Print.
BackgroundK2EDTA contamination of serum samples is a preanalytical error that poses a risk to patient safety. Contamination is most frequently mild to moderate, which standard detection procedures often miss. We examined whether machine learning models ...
BackgroundK2EDTA contamination of serum samples is a preanalytical error that poses a risk to patient safety. Contamination is most frequently mild to moderate, which standard detection procedures often miss. We examined whether machine learning models ...
Optimization of HBsAg retesting process: An improvement in laboratory management system based on health economics
Annals of Clinical Biochemistry, Ahead of Print.
ObjectiveTo optimize the retesting process for hepatitis B screening, reduce false positives in samples with weak positive signals, and improve the laboratory management system, ensuring no missed cases and eliminating resource waste.Methods131 HBsAg-...
ObjectiveTo optimize the retesting process for hepatitis B screening, reduce false positives in samples with weak positive signals, and improve the laboratory management system, ensuring no missed cases and eliminating resource waste.Methods131 HBsAg-...
Evaluating diagnostic accuracy and analytical performance of HELIOS in detecting autoimmune disorders using external proficiency data as a tool: A three-year analysis
Annals of Clinical Biochemistry, Ahead of Print.
ObjectiveTo assess the analytical performance and diagnostic accuracy of an automated analyzer HELIOS in external proficiency testing for diagnosing autoimmune disorders based on antinuclear antibody (ANA) images and titer values.MethodsTotal 09 CAP ...
ObjectiveTo assess the analytical performance and diagnostic accuracy of an automated analyzer HELIOS in external proficiency testing for diagnosing autoimmune disorders based on antinuclear antibody (ANA) images and titer values.MethodsTotal 09 CAP ...
Comparability of serum folate concentration measured by a microbiological method, LC-MS/MS and immunoassay
Annals of Clinical Biochemistry, Ahead of Print.
BackgroundFolate, vitamin B9, is an essential micronutrient for DNA replication and repair. Deficiency is associated with megaloblastic anaemia and fetal neural tube defects. Serum folate measurement provides a convenient biomarker of folate status in ...
BackgroundFolate, vitamin B9, is an essential micronutrient for DNA replication and repair. Deficiency is associated with megaloblastic anaemia and fetal neural tube defects. Serum folate measurement provides a convenient biomarker of folate status in ...
First report of daratumumab interference in urine immunofixation electrophoresis confirmed by the HYDRASHIFT 2/4 Daratumumab assay
Annals of Clinical Biochemistry, Ahead of Print.
A case of analytical interference in urine immunofixation electrophoresis (IFE) caused by daratumumab is presented. Daratumumab, an IgG1-kappa monoclonal antibody, is well-known to produce a false IgG-kappa band in serum IFE, but urinary interference has ...
A case of analytical interference in urine immunofixation electrophoresis (IFE) caused by daratumumab is presented. Daratumumab, an IgG1-kappa monoclonal antibody, is well-known to produce a false IgG-kappa band in serum IFE, but urinary interference has ...
Cryoglobulinaemia is more frequently associated with IgM paraproteins than previously reported, interfering with their quantification, and resulting in potential treatment delays
Annals of Clinical Biochemistry, Ahead of Print.
Pseudo-hypouricemia in four patients with lymphoma and one patient with breast cancer: Interference analysis and elimination
Annals of Clinical Biochemistry, Ahead of Print.
ObjectiveTo investigate the interfering factors and correction methods in the determination of serum uric acid (UA) using the uricase method in patients with elevated immunoglobulin M (IgM).Materials and MethodsIn clinical practice, the UA levels of five ...
ObjectiveTo investigate the interfering factors and correction methods in the determination of serum uric acid (UA) using the uricase method in patients with elevated immunoglobulin M (IgM).Materials and MethodsIn clinical practice, the UA levels of five ...
Preparation and evaluation of in-house multi-analyte quality control materials for ANA, Anti-dsDNA, and autoantibody profile assays
Annals of Clinical Biochemistry, Ahead of Print.
BackgroundThis study explored the preparation and evaluation of in-house quality control (QC) materials for antinuclear antibody (ANA) and anti-double-stranded DNA antibody (anti-dsDNA) testing by indirect immunofluorescence test (IIFT), and ANA profile ...
BackgroundThis study explored the preparation and evaluation of in-house quality control (QC) materials for antinuclear antibody (ANA) and anti-double-stranded DNA antibody (anti-dsDNA) testing by indirect immunofluorescence test (IIFT), and ANA profile ...
Immune checkpoint inhibitors in the real world: A service evaluation of immune-related adverse event incidence and blood test requesting at Portsmouth Hospitals University Trust
Annals of Clinical Biochemistry, Ahead of Print.
BackgroundImmune checkpoint inhibitors (ICI) have revolutionised oncology care but can cause immune-related adverse events (irAE) requiring hospitalisation or lifelong treatment. Diagnosing irAE is complex, and laboratory testing is vital; however, ...
BackgroundImmune checkpoint inhibitors (ICI) have revolutionised oncology care but can cause immune-related adverse events (irAE) requiring hospitalisation or lifelong treatment. Diagnosing irAE is complex, and laboratory testing is vital; however, ...
CORRIGENDUM to “Standardising lipid testing and reporting in the United Kingdom; a joint statement by HEART UK and The Association for Laboratory Medicine”
Annals of Clinical Biochemistry, Ahead of Print.
Is improved folate status in Northern Ireland a result of improved analytical performance or the implementation of folic acid fortification of flour legislation?
Annals of Clinical Biochemistry, Ahead of Print.
Bayesian secondary reanalysis of published aggregate data on circulating tumor DNA for molecular residual disease detection across cancer types
Annals of Clinical Biochemistry, Ahead of Print.
BackgroundCirculating tumor DNA (ctDNA)-based molecular residual disease (MRD) testing may help estimate recurrence risk after treatment. We performed a Bayesian secondary reanalysis of published aggregate data to estimate prognostic and diagnostic ...
BackgroundCirculating tumor DNA (ctDNA)-based molecular residual disease (MRD) testing may help estimate recurrence risk after treatment. We performed a Bayesian secondary reanalysis of published aggregate data to estimate prognostic and diagnostic ...
Untargeted LC-MS/MS profiling identifies ST18 as a novel serum marker for T2DM-associated depression
Annals of Clinical Biochemistry, Ahead of Print.
Depression is a prevalent but underdiagnosed comorbidity in type 2 diabetes mellitus (T2DM), intensifying disease burden and complicating metabolic management. Reliable biomarkers for early detection remain limited. This study aimed to identify serum ...
Depression is a prevalent but underdiagnosed comorbidity in type 2 diabetes mellitus (T2DM), intensifying disease burden and complicating metabolic management. Reliable biomarkers for early detection remain limited. This study aimed to identify serum ...
Stability of electrolytes in whole blood at room temperature prior to centrifugation: Implications for clinical analysis
Annals of Clinical Biochemistry, Ahead of Print.
Background/ObjectivesThe pre-analytical stability of electrolytes in capped whole blood at room temperature remains uncertain due to limited studies and inconsistent findings. This study investigates electrolyte stability during delayed centrifugation, in ...
Background/ObjectivesThe pre-analytical stability of electrolytes in capped whole blood at room temperature remains uncertain due to limited studies and inconsistent findings. This study investigates electrolyte stability during delayed centrifugation, in ...
Commentary on the impact of lithium heparin vacutainer tubes on daily cerebrospinal fluid analysis
Annals of Clinical Biochemistry, Ahead of Print.
Limitations of spectrophotometry in the analysis of cerebrospinal fluid bilirubin
Annals of Clinical Biochemistry, Ahead of Print.
BackgroundCerebrospinal fluid (CSF) spectrophotometry is well-established in the UK for measuring CSF bilirubin and oxyhaemoglobin to aid in the diagnosis of subarachnoid haemorrhage. Although it is known that some antibiotics and large amounts of ...
BackgroundCerebrospinal fluid (CSF) spectrophotometry is well-established in the UK for measuring CSF bilirubin and oxyhaemoglobin to aid in the diagnosis of subarachnoid haemorrhage. Although it is known that some antibiotics and large amounts of ...
