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Table of Contents for Annals of Clinical Biochemistry. List of articles from both the latest and ahead of print issues.
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Preanalytical stability of zinc in whole blood serum and plasma tubes as measured by ICP-OES and colourimetry
Annals of Clinical Biochemistry, Ahead of Print.
BackgroundZinc deficiency is a global concern, particularly in low-income countries, but also among vulnerable groups in Western countries, such as children. Diagnosing mild or moderate zinc deficiency is however challenging because of nonspecific ...
BackgroundZinc deficiency is a global concern, particularly in low-income countries, but also among vulnerable groups in Western countries, such as children. Diagnosing mild or moderate zinc deficiency is however challenging because of nonspecific ...
Predicting the outcome of short Synacthen test based on baseline cortisol levels: A single-centered retrospective cohort study at a tertiary care hospital in Sri Lanka
Annals of Clinical Biochemistry, Ahead of Print.
IntroductionShort Synacthen Test (SST), a standard diagnostic test to confirm Adrenal insufficiency (AI), involves substantial expenses.ObjectivesThis study aimed to assess the predictive value of baseline Cortisol levels for SST outcomes and establish ...
IntroductionShort Synacthen Test (SST), a standard diagnostic test to confirm Adrenal insufficiency (AI), involves substantial expenses.ObjectivesThis study aimed to assess the predictive value of baseline Cortisol levels for SST outcomes and establish ...
Pseudohyperphosphatemia in multiple myeloma: Removal of interfering paraproteins
Annals of Clinical Biochemistry, Ahead of Print.
BackgroundMultiple myeloma patients may present with spuriously elevated serum phosphate levels resulting from the presence of paraproteins interfering in the phosphomolybdate UV assay. If this phenomenon is not recognized, patients possibly receive ...
BackgroundMultiple myeloma patients may present with spuriously elevated serum phosphate levels resulting from the presence of paraproteins interfering in the phosphomolybdate UV assay. If this phenomenon is not recognized, patients possibly receive ...
Thiopurine S-methyltransferase (TPMT) activity cutoffs in the Thai population
Annals of Clinical Biochemistry, Ahead of Print.
BackgroundThiopurine S-methyltransferase (TPMT) is crucial for metabolizing thiopurine drugs. This study aimed to establish the cutoff values for TPMT activity in a cohort of healthy individuals. We defined normal TPMT activity ranges and identified ...
BackgroundThiopurine S-methyltransferase (TPMT) is crucial for metabolizing thiopurine drugs. This study aimed to establish the cutoff values for TPMT activity in a cohort of healthy individuals. We defined normal TPMT activity ranges and identified ...
LabMedUK25 Conference Manchester – Editorial
Annals of Clinical Biochemistry, Volume 62, Issue 5, Page 339-341, September 2025.
Diagnostic accuracy and rapid testing of a novel acute heart failure biomarker: A laboratory evaluation and comparison with natriuretic peptides
Annals of Clinical Biochemistry, Ahead of Print.
BackgroundDiagnosing acute heart failure in patients presenting with acute dyspnea remains challenging. Current methods, including natriuretic peptide measurement and echocardiography, are time-consuming and not always immediately accessible. A novel ...
BackgroundDiagnosing acute heart failure in patients presenting with acute dyspnea remains challenging. Current methods, including natriuretic peptide measurement and echocardiography, are time-consuming and not always immediately accessible. A novel ...
Clinical impact of current evidence on cardiac troponin structure, function and release mechanisms – An up to date review
Annals of Clinical Biochemistry, Ahead of Print.
Myocardial infarction remains a significant cause of mortality globally. High-sensitivity cardiac troponin is an essential criterion in the fourth universal definition of myocardial infarction. Our understanding of the structure and release mechanisms of ...
Myocardial infarction remains a significant cause of mortality globally. High-sensitivity cardiac troponin is an essential criterion in the fourth universal definition of myocardial infarction. Our understanding of the structure and release mechanisms of ...
Procalcitonin assay variation in an Australasian external quality assurance program
Annals of Clinical Biochemistry, Ahead of Print.
Sepsis accounts for approximately 20% of global deaths, and early diagnosis is a critical factor in intervention. In 2017, the FDA approved procalcitonin (PCT) to guide antibiotic use for patients with suspected sepsis, and there are recognized intervals ...
Sepsis accounts for approximately 20% of global deaths, and early diagnosis is a critical factor in intervention. In 2017, the FDA approved procalcitonin (PCT) to guide antibiotic use for patients with suspected sepsis, and there are recognized intervals ...
Real-life evaluation of an alert system to detect the risk of unreported dyskaelemia in haemolysed blood samples from a hospital emergency department
Annals of Clinical Biochemistry, Ahead of Print.
BackgroundIn vitrohaemolysis is a recurrent problem in emergency department samples. Potassium is one of the most critical tests and sensitive to increasing levels ofin vitrohaemolysis. Haemolysis results in a large number of invalidated potassium test ...
BackgroundIn vitrohaemolysis is a recurrent problem in emergency department samples. Potassium is one of the most critical tests and sensitive to increasing levels ofin vitrohaemolysis. Haemolysis results in a large number of invalidated potassium test ...
Kidney stone analysis may miss diagnoses as demonstrated by a case of adenine phosphoribosyl transferase deficiency
Annals of Clinical Biochemistry, Ahead of Print.
Fourier-transformed infrared (FTIR) spectroscopy is a frequently requested test in patients with kidney stones. It is considered particularly useful when routine stone urine screens do not identify any significant abnormalities. This case report describes ...
Fourier-transformed infrared (FTIR) spectroscopy is a frequently requested test in patients with kidney stones. It is considered particularly useful when routine stone urine screens do not identify any significant abnormalities. This case report describes ...
Automated management of internal quality control alarming for secondary measurement channels: An ICT solution
Annals of Clinical Biochemistry, Ahead of Print.
Efficacy and implications of minimum retesting intervals for HbA1c
Annals of Clinical Biochemistry, Ahead of Print.
From analytical interference to the detection of intoxication
Annals of Clinical Biochemistry, Ahead of Print.
This article describes the case of a 66-year-old man who attended the emergency department due to a decrease in the level of consciousness. When determining creatinine in blood plasma using the enzymatic method on the Roche cobas c702® (Roche Diagnostics, ...
This article describes the case of a 66-year-old man who attended the emergency department due to a decrease in the level of consciousness. When determining creatinine in blood plasma using the enzymatic method on the Roche cobas c702® (Roche Diagnostics, ...
Letter response: Metamizole (dipyrone) as an interferent in biochemical assays
Annals of Clinical Biochemistry, Ahead of Print.
Bilirubin interference on a Roche creatinine enzymatic method
Annals of Clinical Biochemistry, Ahead of Print.
Sternal wound infection post cardiac surgery is a preventable complication
Annals of Clinical Biochemistry, Ahead of Print.
Elevated CA19-9 in IgG4-related disease
Annals of Clinical Biochemistry, Ahead of Print.
BackgroundIgG4-related disease (IgG4-RD) is an inflammatory disease that can clinically mimic pancreatic and hepatobiliary cancer. Serum carbohydrate antigen 19-9 (CA19-9) is a tumour marker that is frequently used to aid in the diagnosis of biliary ...
BackgroundIgG4-related disease (IgG4-RD) is an inflammatory disease that can clinically mimic pancreatic and hepatobiliary cancer. Serum carbohydrate antigen 19-9 (CA19-9) is a tumour marker that is frequently used to aid in the diagnosis of biliary ...
Establishment of a reference interval for calculated globulin on the Roche platform
Annals of Clinical Biochemistry, Ahead of Print.
BackgroundCalculated globulin, based on direct measurement of total protein and albumin, can be a useful addition to the routinely requested liver profile. However, a reference interval, established using CLSI EP28-A3c recommended direct methods, is ...
BackgroundCalculated globulin, based on direct measurement of total protein and albumin, can be a useful addition to the routinely requested liver profile. However, a reference interval, established using CLSI EP28-A3c recommended direct methods, is ...
Analysis of first-trimester maternal serum proprotein convertase subtilisin/kexin type 9 (PCSK9) levels as a potential non-invasive biomarker for fetal aneuploidy and NTDs
Annals of Clinical Biochemistry, Ahead of Print.
ObjectivesChromosomal abnormalities and congenital anomalies have huge impact on infant mortality and morbidity. The combined incidence affects approximately 1 per 1000 pregnancies. Current diagnostic modalities include ultrasonography and biomarkers like ...
ObjectivesChromosomal abnormalities and congenital anomalies have huge impact on infant mortality and morbidity. The combined incidence affects approximately 1 per 1000 pregnancies. Current diagnostic modalities include ultrasonography and biomarkers like ...
Validation of the Japan Society of Clinical Chemistry (JSCC) recommended reference measurement procedure for glycated albumin determination
Annals of Clinical Biochemistry, Ahead of Print.
BackgroundTo clarify the fundamental characteristics of the Japan Society of Clinical Chemistry reference measurement procedure (JSCC RMP) for glycated albumin (GA), an additional performance study was performed and the correlation between the HPLC method ...
BackgroundTo clarify the fundamental characteristics of the Japan Society of Clinical Chemistry reference measurement procedure (JSCC RMP) for glycated albumin (GA), an additional performance study was performed and the correlation between the HPLC method ...
