Assay

Histone antibodies

Key Words

Histone antibodies , HIST

Specimen Collection

Serum (Brown)

Turnaround time

10 days

This test is referred to another centre:

Department of Clinical Chemistry and Immunology

Level 4

Addenbrooke’s Hospital NHS Trust

Hills Road

Cambridge

CB2 2QQ

01223 217215

Test indications

Used in cases of drug induced lupus, where patient are more likely to have antibodies directed against the histone moiety of the nucleoprotein complex than to the dsDNA. Drugs implicated in DIL include hydralazine, procainamide and isoniazid. Antibodies can be found in patients with SLE, lupus nephritis and rheumatoid arthritis.

Methodology

Immunoblot

Interferences

Contact referral lab

Reference Range

Contact referral lab

Analytical error

Contact referral lab

Reference change value

Contact referral lab