Assay

Ganglioside antibodies

Key Words

Ganglioside antibodies, glycolipid antibodies

Specimen Collection

Serum (brown)

Turnaround time

21 days                                                                                                                                                                   

 This test is referred to another centre:                                                                                                                            

Department of Immunology                                                                                                                                            

The Churchill Hospital                                                                                                                                         Headington                                                                                                                                                                     

Oxford                                                                                                                                                                    

 OX3 7LJ                                                                                                                                                                 

Tel: 01865 225995                                                                                                                                                          

Fax: 01865 225990

Test indications

These antibodies are associated with the following neurological diseases: 

• IgM anti-GM1 antibodies are associated with acquired motor neuropathies and are found in over 50% of cases.
• IgG anti-GM1 antibodies -although these may be found in a small proportion (5 – 15%) of patients with Guillain-Barré syndrome, their measurement adds little to diagnosis or management.
• IgG anti-GQ1b antibodies are found in over 90% of patients with Miller-Fisher syndrome.
• IgM anti-GQ1b antibodies are associated with a minority of patients with of chronic ataxic sensory neuropathy.

Methodology

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Interferences

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Reference Range

N/A

Analytical error

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Reference change value

N/A