Phospholipase A2 antibody
Assay |
Phospholipase A2 antibody |
Key Words |
PLA2R, Antiphospholipase A2 antibody |
Specimen Collection |
Serum (Brown) |
Turnaround time |
14 days
This test is referred to another centre:
Protein Reference Unit & Immunology Department Laboratory Medicine Building North Lane Northern General Hospital Herries Road Sheffield S5 7AU
0114 226 9196
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Test indications |
Primary (idiopathic) membranous nephropathy
Membranous glomerulonephritis presents with nephrotic syndrome or proteinuria and is identified on renal biopsy by epithelial IgG and C3 deposition. The disease is more common in males than females and has a peak incidence between 40-50 years of age. Membranous nephropathy can be classified as either primary (idiopathic), which occurs in 75% of cases, or secondary. Secondary membranous is associated with malignancy, autoimmunity, infection and drugs. Primary membranous may have an autoimmune component with about 70% cases showing antibodies to M type phospholipase A2 receptor. Phospholipase A2 receptors are transmembrane glycoproteins found in the lungs, placenta, leukocytes and also expressed on podocytes in the kidney. Binding of antibody to PLA2R could cause subepithelial immune complex deposition and complement activation which then results in proteinuria and nephrotic syndrome.
PLA2R antibodies have been shown to be markers for monitoring the patient’s response to immune suppression and can fall to normal range values 3-6 months before there are signs of clinical remission.
PLA2R antibody measurement may have a role in identifying primary from secondary membranous nephropathy and also in disease monitoring. However they should not be viewed as a replacement for renal biopsy in the investigation of patients presenting with nephrotic syndrome.
|
Methodology |
ELISA |
Interferences |
Contact referral lab |
Reference Range |
Negative = <13 RU/mL
|
Analytical error |
Contact referral lab |
Reference change value |
Contact referral lab |